Browsing by Author "Dai, Zen-Kong"

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Exogenous Heat Shock Cognate Protein 70 Suppresses LPS-Induced Inflammation by Down-Regulating NF-κB through MAPK and MMP-2/-9 Pathways in Macrophages

Sulistyowati, Erna; Lee, Mei-Yueh; Wu, Lin-Chi; Hsu, Jong-Hau; Dai, Zen-Kong; Wu, Bin-Nan; Lin, Ming-Chung; Yeh, Jwu-Lai (MDPI journals, 2018-08-23)

Heat shock cognate protein 70 (HSC70), a molecular chaperone, is constitutively expressed by mammalian cells to regulate various cellular functions. It is associated with many diseases and is a potential therapeutic ...
In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis

Huang, Shang-En; Sulistyowati, Erna; Chao, Yu-Ying; Wu, Bin-Nan; Dai, Zen-Kong; Hsu, Jong-Hau; Yeh, Jwu-Lai (National Library of Medicine, 2021-05-28)

Osteoarthritis is a degenerative arthropathy that is mainly characterized by dysregulation of inflammatory responses. KMUP-1, a derived chemical synthetic of xanthine, has been shown to have anti-inflammatory and antioxidant ...
KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO–cGMP–MAPK Signaling Pathways

Lee, Meng-Luen; Sulistyowati, Erna; Hsu, Jong-Hau; Huang, Bo-Yau; Dai, Zen-Kong; Wu, Bin-Nan; Chao, Yu-Ying; Yeh, Jwu-Lai (MDPI journals, 2019-04-08)

To test whether KMUP-1 (7-[2-[4-(2-chlorophenyl) piperazinyl]ethyl]-1,3-dimethylxanthine) prevents myocardial ischemia-induced apoptosis, we examined KMUP-1-treated H9c2 cells culture. Recent attention has focused on the ...

Browsing by Author "Dai, Zen-Kong"

Browsing by Author "Dai, Zen-Kong"

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