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dc.contributor.authorAthiroh, Nour
dc.contributor.authorWahyuningsih, Doti
dc.date.accessioned2021-10-14T04:04:52Z
dc.date.available2021-10-14T04:04:52Z
dc.date.issued2017-03
dc.identifier.issn2502-5600
dc.identifier.urihttp://jurnal.unsyiah.ac.id/JKH/article/view/5431
dc.identifier.urihttp://repository.unisma.ac.id/handle/123456789/2065
dc.description[ARCHIVES] Copyright Article from : Jurnal Kedokteran Hewan, http://jurnal.unsyiah.ac.id/JKH/article/view/5431en_US
dc.description.abstractThe aim of this research was to investigate the potential effect of methanolic extract of Scurrula atropurpurea (MESA) in reducing oxidative stress through observation of superoxide dismutase (SOD) activity and malondialdehyde (MDA) concentration in mice. In this research, 25 male mice were divided into four groups with five replications. Group I (K1, without MESA) was considered as a control group, while Group II (K2), III (K3), and IV (K4) were given 1000, 2000, and 4000 mg MESA/kg BW, respectively. After 14 days, SOD activity and MDA concentration were measured spectrophotometrically. The SOD activity did not significantly increased (P>0.05) in group K1, K2, K3, and K4 with values were 19.469±2.072, 17.4±1.373, 20.53±3.411, and 23.87±2.528 U/ml, respectively. In contrast, MDA concentration was decreased (P>0.05) with values of 492.750±19.418, 492.750±19.418, 457.125±30.095, 454.625±19.080, and 475.875±37.659 ng/mL in groups K1, K2, K3, and K4, respectively. It can be concluded that the administration of MESA tend to increase SOD activity and decrease MDA concentration in this study, thus might be able to reduce oxidative stress in mice.en_US
dc.language.isootheren_US
dc.publisherJurnal Kedokteran Hewanen_US
dc.relation.ispartofseriesVol 11, No 1;19-22
dc.subjectAcute Toxicityen_US
dc.subjectMESAen_US
dc.subjectMiceen_US
dc.subjectOxidative Stressen_US
dc.titleStudy of Superoxide Dismutase and Malondialdehyde Concentrations in Mice After Administration of Methanolic Extract of Scurrula atropurpurea (BL.)en_US
dc.typeArticleen_US


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