Role of Superoxide Dismutases (SODs) in Hypertensive Rats After Administration of Mango Mistletoe Methanolic Extract

Abstract

Hypertension is an abnormal rising blood pressure that caused of cardiovascular disease. Hypertension induces free radicals production such as reactive oxygen species (ROS) and oxidative stress.This study aimed to investigatethe potential effect of Dendropthoe pentandra as an endogenous antioxidant modulator for superoxide dismutase (SOD) in hypertensive rats. Samples were obtained using SOD levels measurement from the lungs of hypertensive rats.Twenty-five male rats were divided into five groups, five rats each group. The groups are normal control rats, hypertensive rats (HT)without methanolic extract of mango mistletoe, hypertensive rats with 50 mg/kg, 100 mg/kg, and 200 mg/kg BW of methanolic extract of mango mistletoe. Data were analyzed using the one-way ANOVA test and the Post Hoc test to see variations in SOD levels in different treatments. The results of the study obtained that DOCA-salt induction was increased the rat's blood pressure which causes the rats to become hypertensive.The administration of mango mistletoe methanolic extract at a dose of 50 mg/kg, 100 mg/kg, and 200 mg/kg BW increased SOD levels compared to HR and normal control groups. The levels of increased lung SOD with extract methanolic of mango mistletoe dosage variations in all treatment groups were not different. The administration of mango mistletoe methanolic extract at a dose of 50 mg / kgBW was optimum in increasing lung SOD levels in hypertensive rats.