Antioxidative and blood pressure-lowering effects of Scurrula atropurpurea on deoxycorticosterone acetate–salt hypertensive rats

Athiroh, Nour; Permatasari, Nur; Sargowo, Djanggan; Widodo, M. Aris

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dc.contributor.author	Athiroh, Nour
dc.contributor.author	Permatasari, Nur
dc.contributor.author	Sargowo, Djanggan
dc.contributor.author	Widodo, M. Aris
dc.date.accessioned	2023-02-07T02:02:10Z
dc.date.available	2023-02-07T02:02:10Z
dc.date.issued	2014-03-01
dc.identifier.uri	https://doi.org/10.1016/j.bgm.2014.01.001
dc.identifier.uri	http://repository.unisma.ac.id/handle/123456789/6532
dc.description	[ARCHIVES] Copyright Article from: Biomarkers and Genomic Medicine	en_US
dc.description.abstract	This study aimed to investigate whether a methanolic extract of Scurrula atropurpurea (BL.) Dans. (MESA) was able to reduced oxidative stress and systolic blood pressure (SBP) in deoxycorticosterone acetate–salt hypertensive rats. Twenty-five male Wistar were divided into the control group and four hypertensive groups that received the MESA at a doses of 50 mg/kg, 100 mg/kg, or 200 mg/kg bodyweight, or received no MESA. SBP was recorded by tail cuff methods. The levels of serum malondialdehyde (MDA) and superoxide dismutase (SOD) were analyzed by colorimetry. SBP was increased significantly in the hypertensive group compared to the sham group (p < 0.05). Administration of MESA significantly decreased SBP, but not to reach the level of the sham group. The level of MDA was significantly higher in the hypertensive group compared to the sham group (p < 0.05). Administration of MESA200 significantly decreased the MDA levels compared to HR groups (p < 0.05). The SOD level was significantly decreased in HR compared to the sham group (p < 0.05). Administration of MESA50 elevated the SOD levels to reach the level in the sham group. The SOD levels in MESA100 and MESA200 were significantly higher compared to the sham group (p < 0.05). In conclusion, Scurulla atropurpurea is able to modulate SOD, diminish oxidative stress, and decrease SBP in deoxycorticosterone acetate–salt hypertensive rats.	en_US
dc.language.iso	en	en_US
dc.publisher	Biomarkers and Genomic Medicine	en_US
dc.relation.ispartofseries	Volume 6, Issue 1;
dc.subject	high blood pressure	en_US
dc.subject	antioxidant	en_US
dc.title	Antioxidative and blood pressure-lowering effects of Scurrula atropurpurea on deoxycorticosterone acetate–salt hypertensive rats	en_US
dc.type	Article	en_US