Evaluation of Methanolic Extract of Scurrula Atropurpurea (Bl.) Dans Sub-Chronic Exposure On Wistar Rat Liver

Abstract

Background: This study aimed to analyze sub-chronically exposure of methanolic extract of Scurrula atropurpurea (Bl.) Dans (MESA) on rat liver function such as AST (aspartate transferase), ALT (alanine transaminase), level of serum albumin, level of serum globuline level of total serum protein, and histopathology of liver. Objectives: Male Wistar rats were randomly divided into four groups: control, MESA I (250 mg/BW), MESA II (500 mg/BW), MESA III (1000 mg/BW). Methanolic extract was given once daily per oral for 28 days. Body weight were measured twice weekly. Data were analyzed by one way ANOVA test and continued by Post Hoc test on SPSS 21 software. Results: No effect were found on orally exposure of MESA for 28 days compared to the control, on rat level of serum AST, serum ALT, level of serum albumin, level of serum globuline and level of total serum protein (p > 0.05). That besides no abnormality in liver histopathology in treatment. Conclusion: This study concluded sub-chronic exposure of MESA did not interfered rat liver function. It would be a recommendation for next clinical study