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http://repository.unisma.ac.id/handle/123456789/2024
Title: | Dietary Ethanolic Extract of Mangosteen pericarp Reduces VCAM-1, Perivascular Adipose Tissue and Aortic Intimal Medial Thickness in Hypercholesterolemic Rat Model |
Authors: | Wihastuti, Titin Andri Aini, Fitria Nugraha Tjahjono, Cholid Tri Heriansyah, Teuku |
Keywords: | Atherosclerosis Dyslipidemia Mangosteen Pericarp Ethanolic Extract VCAM-1 PVAT IMT |
Issue Date: | 10-Oct-2019 |
Publisher: | US National Library of Medicine National Institutes of Health |
Series/Report no.: | Macedonian Journal of Medical Sciences;Vol.7, Issue 19, Page 3158-3163 |
Abstract: | BACKGROUND: High-fat diet (HFD) is associated with dyslipidemia which is a risk factor for atherosclerosis. Dyslipidemia causes oxidative stress which induces vascular cell adhesion molecule-1 (VCAM-1). Oxidative stress also triggers the thickening of tunica intima-media (IMT) and Perivascular Adipose Tissue (PVAT). Xanthone compound in ethanolic extract of Mangosteen pericarp (EEMP) has an antioxidant property to overcome the oxidative stress. AIM: The objective of this study is to investigate the effect of dietary EEMP administration on the expression of VCAM-1 and thickness of PVAT and IMT in atherosclerotic rat model fed with HFD. METHODS: This experimental laboratory study uses 25 Wistar strain Rattus norvegicus which were divided into 5 study groups. Negative Control group (GT1) was given a normal diet, Positive Control group (GT2) was treated with HFD, and three treatment groups were each treated with HFD with Mangosteen pericarp extract of 200 mg/kg BW (GT3), 400 mg/kg BW (GT4), and 800 mg/kg BW (GT5). Measurements of VCAM-1 expression were performed using immunofluorescence. PVAT and IMT measurements were performed on rat aortic preparations. RESULTS: One-way ANOVA test showed the addition of dietary EEMP significantly (p < 0.05) decreased the expression of VCAM-1 and decreased the thickness of PVAT and IMT in treatment groups as compared with both negative and positive controls. Tukey HSD test showed a dose of 800 mg/kg BW was the most effective dose for decreasing VCAM-1 level, PVAT and IMT. CONCLUSION: Dietary EEMP significantly decreases the expression of VCAM-1, as well as the thickness of PVAT and IMT in Wistar strain Rattus norvegicus treated with HFD. |
Description: | [ARCHIVES] Copyright Article from: Macedonian Journal of Medical Sciences (US National Library of Medicine National Institutes of Health) |
URI: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953934/ http://repository.unisma.ac.id/handle/123456789/2024 |
ISSN: | 3158–3163 |
Appears in Collections: | LP - Medical Education |
Files in This Item:
File | Description | Size | Format | |
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dr. Fitria Nugraha Aini 1-OAMJMS-7-3158.pdf | Document | 429.33 kB | Adobe PDF | View/Open |
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