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http://repository.unisma.ac.id/handle/123456789/2026
Title: | Anti-Inflammatory Activity of Agaricus Blazei Murill Extract In The Spleen of Mice Fed a High-Fat Diet |
Authors: | Kurniawan, Dicky Sargowo, Djanggan Tjokroprawiro, Askandar Rifa'i, Muhaimin |
Keywords: | Anti-inflammatory agent Agaricus blazei Murill Proinflammatory cytokine TNF-α IL-10 |
Issue Date: | 31-Mar-2018 |
Publisher: | Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria |
Series/Report no.: | Tropical Journal of Pharmaceutical Research;Vol.17, Issue 3, Page 483-489 |
Abstract: | urpose: To examine the effects of A. blazei Murill on the production of proinflammatory cytokine TNF-α and regulatory cytokine IL-10 in the spleen of mice fed a high-fat diet. Methods: The study was conducted on 25 BALB/c male mice divided into five groups consisting of five mice in each group and utilized three A. blazei Murill extract doses: 100, 200 and 400 mg/kg. The mice were fed a high-fat diet (HFD) and given A. blazei Murill extract for 12 weeks. The relative number of CD4+TNF-α+, CD11b/c+TNF-α+, and CD4+CD25+IL-10+ were measured using flow cytometry. Results: Oral administration of A. blazei Murill extract (100 mg/kg) in mice fed a high-fat diet significantly decreased (p < 0.05) the level of TNF-α that produced by CD4+ T cells and macrophages (1.64 %), compared with control. The 200 mg/kg dose decreased the level of CD11b/c+TNF-α+ by 5.37 % (p < 0.05) compared to 100 mg/kg dose. The 400 mg/kg dose significantly enhanced regulatory cytokines IL-10 by 17.56 % (p < 0.05) in mice fed a high-fat diet. Conclusion: This findings suggest that Agaricus blazei Murill can inhibits processes in HFD-induced mice by reducing TNF-α production and increasing the anti-inflammatory cytokine IL-10. These results provide new insight into the pharmacological actions of Agaricus blazei Murill as a medicinal food for potential therapy of atherosclerosis disease |
Description: | [ARCHIVES] Copyright Article from: Tropical Journal of Pharmaceitical Research (Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria) |
URI: | https://www.tjpr.org/home/abstract.php?id=2087&aTitle=Anti-inflammatory%20activity%20of%20Agaricus%20blazei%20Murill%20extract%20in%20the%20spleen%20of%20mice%20fed%20a%20high-fat%20diet http://repository.unisma.ac.id/handle/123456789/2026 |
ISSN: | 1596-9827 |
Appears in Collections: | LP - Medical Education |
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dr.dicky-2- 2018_17_3_14.pdf | Document | 338.04 kB | Adobe PDF | View/Open |
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