Uji Toksisitas Ekstrak Metanolik Kombinasi Daun Benalu Teh dan Daun Benalu Mangga terhadap Profil Lipid Tikus Betina (Rattus norvegicus) pada Paparan Sub-Kronik 28 Hari

Abstract

Tea Benalu (Scurrula atropurpurea [Bl.] Dans.) and Mango Benalu (Dendrophthoe pentandra L. miq.) Belong to Teh Loranthaceae family which contains secondary metabolites with potential antioxidant potential. Antioxidants can inhibit Teh oxidation process and reduce Total Cholesterol, Triglycerides, Low-Density Lipoprotein (LDL) and increase High-Density Lipoprotein (HDL). Teh safety of Teh preparations for Teh combination of parasites of tea and mango leaves was tested to obtain toxic effects after repeated treatment tests over some time. Teh purpose of this study was to determine Teh toxic effects of a combination of methanolic extracts of a combination of tea parasites and mangoes in female rats (Rattus norvegicus) subchronically for 28 days by looking at Teh results of Teh clinical biochemical examination on lipid profiles, namely total cholesterol levels, triglycerides, High-Density Lipoprotein (HDL), and Low-Density Lipoprotein (LDL). Teh method of this study was experimental with a combination dose of methanol extract of tea parasite leaves and mango parasite leaves at a dose of 250 mg/KgBB, 500 mg/KgBB and 1000 mg/KgBB with 5x replications each treatment. Teh subjects used white rats (Rattus norvegicus) female Wistar strains aged 6-8 weeks with a minimum body weight of 100 grams. Teh treatment in this study was in Teh form of each dose given 5 times a week for 28 days (subchronic toxicity test) orally. Lipid profile levels were analyzed using Teh one-way ANOVA test. Teh results showed that Teh level of control blood lipid profile with a treatment dose of 250 mg / KgBB, 500 mg / KgBB, and 1000 mg / KgBB was not significantly different. Teh toxicity test of combined extracts of tea leaves and mango parasite leaves of female rat Rattus novergicus on subchronic exposure 28 days with a dose 250 mg/KgBB, 500 mg/KgBB and 1000 mg/KgBB showed no difference tangible between treatment of controls. This means it is safe and does not cause toxic properties in Teh lipid profile of female wistar rats. Keywords: Lipid Profile, Scurrula atropurpurea, Dendophthoe pentandra, Sub-Chronic Toxicity, Rattus norvegicus