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Title: | Molecular Docking of Soybean (Glycine max) Seed and Ginger (Zingiber officinale) Rhizome Components as Anti-Diabetic Through Inhibition of Dipeptidyl Peptidase 4 (DPP-4) and Alpha-Glucosidase Enzymes |
Authors: | Purnomo, Yudi Taufiq, Muhammad Wijaya, Afnan N. D. Hakim, Reza |
Keywords: | Anti-diabetic Glycine DPP-4 α-glucosidase |
Issue Date: | 1-Oct-2021 |
Publisher: | Tropical Journal of Natural Product Research |
Citation: | Purnomo, Y., Taufiq, M., N. D. Wijaya, A., & Hakim, R. (2021). Molecular Docking of Soybean (Glycine max) Seed and Ginger (Zingiber officinale) Rhizome Components as Anti-Diabetic Through Inhibition of Dipeptidyl Peptidase 4 (DPP-4) and Alpha-Glucosidase Enzymes: doi.org/10.26538/tjnpr/v5i10.7. Tropical Journal of Natural Product Research (TJNPR), 5(10), 1735–1742. Retrieved from https://www.tjnpr.org/index.php/home/article/view/374 |
Series/Report no.: | Tropical Journal of Natural Product Research;Vol 5, No 10 |
Abstract: | Dipeptidyl Peptidase-4 (DPP-4) and alpha-glucosidase (α-glucosidase) are enzymes involved in carbohydrate metabolism. Inhibition of these enzymes contribute to blood glucose level suppression. Soybean (Glycine max) seeds and ginger (Zingiber officinale) rhizome are herbs that have anti-diabetic activity. The mechanism of action, however, has not been thoroughly explored. This study aims to evaluate the anti-diabetic potentials of the chemical components in soybean seeds and ginger rhizome through inhibition activity of DPP-4 and α-glucosidase in silico. Soybean seed and ginger rhizome were extracted using the maceration method with ethanol solvent. Ethanol extract of soybean seeds and ginger rhizome were analysed using Liquid Chromatography-Mass Spectrometry (LC-MS/MS). The potency of active compounds from the plants on DPP-4 and α-glucosidase were evaluated by in silico study using web-based software (Docking server). Soybean seed were found to contain phytosterols, mainly beta sitosterol, campesterol, stigmasterol, and lanosterol. Meanwhile, ginger rhizome was found to contain 6-gingerdiol, 10-gingerol and 12-shogaol. Molecular docking study showed that stigmasterol and 12-shogaol strongly inhibits DPP-4 activity while stigmasterol and 6-Gingerdiol strongly inhibited α-glucosidase. This shows that both soybean seed and ginger rhizome potentially act as an anti-diabetic by inhibiting DPP-4 and α-glucosidase; however, soybean seed is more potent due to its ability to inhibit both of the tested enzymes. |
Description: | [ARCHIVES] Copyright Article From:Tropical Journal of Natural Product Research (TJNPR) |
URI: | https://www.tjnpr.org/index.php/home/article/view/374 http://repository.unisma.ac.id/handle/123456789/6190 |
ISSN: | 2616-0692 |
Appears in Collections: | LP - Pharmaceutical |
Files in This Item:
File | Description | Size | Format | |
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Corr-TJNPR_Moleculardock.pdf | 2 MB | Adobe PDF | View/Open | |
8 TJNPR_ALL.pdf | 5.14 MB | Adobe PDF | View/Open | |
8 TJNPR_ALL_rev.pdf | Content | 7.44 MB | Adobe PDF | View/Open |
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