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DC Field | Value | Language |
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dc.contributor.author | Purnomo, Yudi | - |
dc.contributor.author | Soeatmadji, D.W | - |
dc.contributor.author | Sumitro, S.B | - |
dc.contributor.author | Widodo, M.A | - |
dc.date.accessioned | 2023-01-18T16:08:21Z | - |
dc.date.available | 2023-01-18T16:08:21Z | - |
dc.date.issued | 2015-01-19 | - |
dc.identifier.issn | 0975-4873 | - |
dc.identifier.uri | http://impactfactor.org/PDF/IJPPR/7/IJPPR,Vol7,Issue5,Article33.pdf | - |
dc.identifier.uri | http://repository.unisma.ac.id/handle/123456789/6323 | - |
dc.description | [ARCHIVES] Copyright Article from: International Journal of Pharmacognosy and Phytochemical Research 2015; 7(5); 1073-1079 | en_US |
dc.description.abstract | Glucagon Like Peptide-1 (GLP-1) is one of incretin hormone which is proposed as a new therapy for type 2 diabetes (T2DM). However, this hormone is metabolized excessively by Dipeptidyl Peptidase IV (DPP-IV) into inactive form. The inhibition of DPP-IV can prolong GLP-1 bioavailability for regulating blood glucose level on T2DM. Urena lobata is a plant which has been used to cure T2DM empirically but the inhibitory activity on DPP-IV has not been tested. The aim of the study was to evaluate anti diabetic effect of U. lobata leaf extract through DPP-IV inhibition. Urena lobata leaf was extracted in ethanol solvent and hot water then evaporated till pasta form. The object study was used animal model of T2DM which divided into 2 control group and 6 test group (n=4) and then DPP-IV level, GLP-1, insulin and blood glucose AUC were examined after supplemented U. lobata leaf extract. All data are expressed as the mean ± SD and analyzed with one way anova and then continued with LSD and Dunnet c (p<0.05). Both of water and ethanolic extract from U. lobata decrease DPP-IV level and blood glucose AUC compared to control group (p<0.05) whereas insulin level and GLP-1 are increased (p<0.05). It was controlled by stigmasterol, β-sitosterol and mangiferin having anti-diabetic effect by inhibiting DPP-IV. Water extract of U. lobata stronger decrease DPP-IV level and blood glucose AUC and also increase insulin level and GLP-1 compared to ethanolic extract (p<0.05). The conformation change of active substances result a poor solubility and absorption in ethanol extract contribute to decrease their biology activity. | en_US |
dc.language.iso | en | en_US |
dc.publisher | International Journal of Pharmacognosy and Phytochemical research (IJPPR) | en_US |
dc.relation.ispartofseries | International Journal of Pharmacognosy and Phytochemical Research 2015;7(5); 1073-1079 | - |
dc.subject | Diabetes mellitus type II | en_US |
dc.subject | DPP-IV | en_US |
dc.subject | GLP-1 | en_US |
dc.subject | Insulin | en_US |
dc.subject | Urena lobata | en_US |
dc.title | Anti-hiperglycemic Effect of Urena lobata Leaf Extract by Inhibition of Dipeptidyl Peptidase IV ( DPP-IV ) on Diabetic Rats | en_US |
dc.type | Article | en_US |
Appears in Collections: | LP - Pharmaceutical |
Files in This Item:
File | Description | Size | Format | |
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Corr_IJPPR_antihipergly.pdf | Content | 2.11 MB | Adobe PDF | View/Open |
2 IJPPR_ALL.pdf | 1.72 MB | Adobe PDF | View/Open |
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