Background: Type 2 diabetes mellitus (T2DM) is a progressive chronic disease characterized by hyperglycemia due to insulin resistance. Leptin is a hormone produced by adipocytes which plays a role to control of appetite, weight, energy homeostasis and control of blood glucose levels. Leptin is found to mediate insulin secretion and resistance in peripheral tissues. This study aims to look at the role of glucose control on serum leptin levels in T2DM patients. Method: This research was cross sectional study. The respondents are male and female patients diagnosed with T2DM without complications over the age of 40 years. The subjects divided into the controlled group and uncontrolled group. Each control group of data respectively will depend on the serum leptin level using the Human Leptin Elisa Kit EZHL-80SK. Statistical analysis was done by Independent T-Test and Spearman’s correlation test with a significance level of p<0,05. Result: Serum leptin levels in the uncontrolled group (3.96 ± 2.63) were lower than those in the controlled group (4,04 ± 2,11), but no significant (p=0,756). Leptin was positively correlated but not significant with HbA1c (r=0,178, p=0,329) and serum glucose (r=0,014, p=0,926). Leptin was negatively correlated and not significant with random blood glucose (r=-0,066, p=0,704). This happened allegedly due to an error in the storage and management of serum samples before use. Conclusion: Glucose control has no role in serum leptin levels towards patients with type 2 DM. Keyword: glucose control, leptin serum, type 2 diabetes mellitus.