Sub chronic diagnosis of administration with Scurrula atropurpurea to blood biochemichal analysis

Athiroh, N; Purnomo, Y; Mubarakati, N J

Dalam rangka peningkatan layanan dan perbaikan sistem, mohon maaf untuk sementara waktu Repositori UNISMA tidak dapat diakses secara optimal.

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dc.contributor.author	Athiroh, N
dc.contributor.author	Purnomo, Y
dc.contributor.author	Mubarakati, N J
dc.date.accessioned	2023-02-07T03:17:42Z
dc.date.available	2023-02-07T03:17:42Z
dc.date.issued	2020
dc.identifier.citation	N Athiroh et al 2020 IOP Conf. Ser.: Mater. Sci. Eng. 846 012002	en_US
dc.identifier.uri	10.1088/1757-899X/846/1/012002
dc.identifier.uri	http://repository.unisma.ac.id/handle/123456789/6547
dc.description	[ARCHIVES] Copyright Article from : IOP Publishing Ltd	en_US
dc.description.abstract	This research is to evaluate whether Scurrula atropurpurea has a protective effect on the liver caused by its sub-chronic treatment. The rats consist of four groups: normotensive group and three groups administered methanolic extract of S. atropurpurea (MESA) at a dosage of 250; 500; and 1000 mg/kg BW. Serum liver and kidney function were assayed. Serum cholesterol was checked. Histopathology of the brain, liver, cardiac, lung, and kidney was identified using hematoxylin-eosin staining. The administration of MESA250, MESA500 and MESA1000 caused no differences among the groups compared with the control group. Structural evaluations on the brain and lungs showed that the MESA administration carried no changes. In liver and heart, MESA1000 led to repair tissue damage. But for the kidney, MESA250 was safe for the tissue. The results of this study revealed that the methanolic extract of S. atropurpurea at antihypertension dose is safe even when taken for a more extended period. At a higher dose, the extract may have the potential to increase some hematological indices but may induce tissue repair in the liver and heart. The lowest dose is safe for kidney tissue.	en_US
dc.language.iso	en	en_US
dc.publisher	IOP Publishing Ltd	en_US
dc.subject	Sub chronic diagnosis	en_US
dc.subject	biochemichal analysis	en_US
dc.subject	Scurrula atropurpurea	en_US
dc.title	Sub chronic diagnosis of administration with Scurrula atropurpurea to blood biochemichal analysis	en_US
dc.type	Article	en_US