Abstract:
This research is to evaluate whether Scurrula atropurpurea has a protective effect on the liver caused by its sub-chronic treatment. The rats consist of four groups: normotensive group and three groups administered methanolic extract of S. atropurpurea (MESA) at a dosage of 250; 500; and 1000 mg/kg BW. Serum liver and kidney function were assayed. Serum cholesterol was checked. Histopathology of the brain, liver, cardiac, lung, and kidney was identified using hematoxylin-eosin staining. The administration of MESA250, MESA500 and MESA1000 caused no differences among the groups compared with the control group. Structural evaluations on the brain and lungs showed that the MESA administration carried no changes. In liver and heart, MESA1000 led to repair tissue damage. But for the kidney, MESA250 was safe for the tissue. The results of this study revealed that the methanolic extract of S. atropurpurea at antihypertension dose is safe even when taken for a more extended period. At a higher dose, the extract may have the potential to increase some hematological indices but may induce tissue repair in the liver and heart. The lowest dose is safe for kidney tissue.
