Abstract:
Background: Atopic dermatitis is a chronic, recurrent inflammation
of the skin, accompanied by severe pruritus. Immune system
dysregulation and skin barrier defects are associated with the
abnormalities in atopic dermatitis. Myriad pieces of evidence
have pointed to the major roles of LL-37 and interleukin-31 (IL31) in atopic dermatitis. The studies on atopic dermatitis are still
limited in Indonesia, particularly in Malang city. The objective of
the present study was to understand the association of LL-37 and
IL-31 serum levels with SCORing Atopic Dermatitis (SCORAD)
in atopic dermatitis patients.
Methods: The present research is an analytical observational
cross-sectional study with 30 atopic dermatitis patients as subjects.
Through a consecutive sampling method, samples were collected
from the outpatient clinics of dermatovenereology and pediatric
department, Dr. Saiful Anwar General Hospital (RSSA), Malang,
Indonesia. LL-37 and IL-31 serum levels were examined via
Enzyme-Linked Immunosorbent Assay (ELISA) method. Subjects
were allocated into two groups of atopic dermatitis severity, mild
and moderate-severe, based on the SCORAD index.
Results: Based on the Pearson correlation test, there was no
correlation between LL-37 serum level, IL-31 serum level and the
SCORAD score (r=-0.238 with P=0.205, and r=0.15 with P=0.939).
Conclusion: LL-37 and IL-31 serum levels are not associated
with atopic dermatitis severity.
