In the field of language teaching, vocabulary is the language resource. Students have to know vocabularies to produce sentences. Thus, the aim of this study was to find out the students’ ability of vocabulary learning by using picture card as a media or without using picture card as a media, and whether picture card could improve students’ vocabulary mastery or not. This study employed quasi-experimental research design. The experimental class was taught by using picture cards, and the control class was not taught by using picture cards. The populations in seventh grade students of Mts Al-Khoirot Karangsuko consist of 215 students; the sample was 40 students (20 students’ experimental class and 20 students controlled class). Moreover, this research was conducted through the following procedures: giving pretest, applying treatments, and giving posttest. The data analyzed in this research was gathered through test, after getting the score from the test, score was analyzed and processed by using statistic data calculation of T-test formula by using SPSS. The result of the research proved that there was a difference between the mean score of th experimental class and the control class. Based on the data analysis, the significant column value of t-test was 0.003 it was less than 0.05, it indicated that the result of t-test analysis was significant. In addition, the results simply contribute to make students became more enthusiastic and active doing the learning process. This was also giving the evidence for this study the picture card technique, so the teacher can pick the appropriate technique to achieve the goal of teaching learning process, especially in mastering vocabulary. The result of this study was shown that picture card could give effect for students’ vocabulary learning due to the test score of experimental group was higher than the control group. Accordingly, related to the result of this experimental research, the researcher concludes that picture card can be used as the alternative teaching media to improve students’ vocabulary learning in the seventh grade of Junior High School.