Synthesis, Method Optimization of 2,3-Disubtitutedquinazolin-4(3H)-One

Widiyana, Anita P; Putra, Galih S; Sulistyowati, Mellany Ika; Hardjono, Suko; Budiati, Tutuk

dc.contributor.author	Widiyana, Anita P
dc.contributor.author	Putra, Galih S
dc.contributor.author	Sulistyowati, Mellany Ika
dc.contributor.author	Hardjono, Suko
dc.contributor.author	Budiati, Tutuk
dc.date.accessioned	2021-10-11T06:18:27Z
dc.date.available	2021-10-11T06:18:27Z
dc.date.issued	2017-08-01
dc.identifier.issn	0975-7383
dc.identifier.uri	https://www.jocpr.com/abstract/synthesis-method-optimization-of-23disubtitutedquinazolin43hone-derivatives-8955.html
dc.identifier.uri	http://repository.unisma.ac.id/handle/123456789/1920
dc.description	[ARCHIVES] Copyright Article from: Journal of Chemical and Pharmaceutical Research	en_US
dc.description.abstract	Quinzolinones have various biological activities such as anticancer, antidiabetic, anticonvulsant, antihistaminic, anti inflammatory, antifungal, anthelmintics and antiviral activites. In this research some of compounds 2,3- disubtitutedquinazolin-4(3H)-one derivatives had been synthesized under microwave irradiation. The compounds were obtained from reaction some of benzoxazine derivatives with hydrazine hydrate using microwave irradiation and the result of reaction we obtained 82-96%. The productshad been tested by IR, 1H-NMR, 13C-NMR and Mass Spectroscopy analysis. The using microwave irradiation was more effective and efficient to produce compounds 2,3-disubtituted quinazolin-4(3H)-one derivative because the reaction runs perfectly without any minor products such as compounds N-(2-(hydrazinecarbonyl)phenyl)benzamide derivatives.	en_US
dc.language.iso	en	en_US
dc.publisher	Journal of Chemical and Pharmaceutical Research (JOCPR)	en_US
dc.relation.ispartofseries	Journal of Chemical and Pharmaceutical Research (JOCPR);Vol.9, Issue 8, Page 24-28
dc.subject	2,3-disubtituted quinazolin-4(3H)-one derivatives	en_US
dc.subject	N-(2-(hydrazinecarbonyl)phenyl)benzamide derivatives	en_US
dc.subject	Microwave irradiation	en_US
dc.title	Synthesis, Method Optimization of 2,3-Disubtitutedquinazolin-4(3H)-One	en_US
dc.type	Article	en_US