• In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis 

  Huang, Shang-En; Sulistyowati, Erna; Chao, Yu-Ying; Wu, Bin-Nan; Dai, Zen-Kong; Hsu, Jong-Hau; Yeh, Jwu-Lai (National Library of Medicine, 2021-05-28)

  Osteoarthritis is a degenerative arthropathy that is mainly characterized by dysregulation of inflammatory responses. KMUP-1, a derived chemical synthetic of xanthine, has been shown to have anti-inflammatory and antioxidant ...
• Effect of Extraction Method on Antimicrobial Activity Against Staphylococcus Aureus of Tapak Liman (Elephantopus Scaber L.) Leaves 

  Widyaningrum, Ike; Wibisono, Nugroho; Kusumawati, Anggun Hari (International journal of Health & Medical Sciences, 2020-10-18)

  This study aims to compare the antibacterial activity of Staphylococcus aureus from tapak liman leaf extract using different extraction methods, maceration, and soxhletation. Maceration is a type of cold extraction, ...
• Vasculoprotective Effects of Centella Asiatica, Justicia Gendarussa and Imperata Cylindrica Decoction via the NOXs-ROS-NF-κB Pathway in Spontaneously Hypertensive Rats 

  Sulistyowati, Erna; Jan, Ren-Long; Liou, Shu-Fen; Chen, Ying-Fu; Wu, Bin-Nan; Hsu, Jong-Hau; Yeh, Jwu-Lai (Elsevier, 2019-06-24)

  Background and aim: Centella asiatica,Justicia gendarussaandImperata cylindricadecoction (CJID) isefficacious for hypertension. NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX)-induced reactive oxygen ...
• Association of LL-37 and IL-31 Serum Levels with SCORing Atopic Dermatitis (SCORAD) Score in Atopic Dermatitis Patients 

  Brahmanti, Herwinda; Rofiq, Aunur; Cholis, Moch; Trijayanti, Unundya; Purwanti, Sasi (Iranian Journal of Dermatology, 2018-05-12)

  Background: Atopic dermatitis is a chronic, recurrent inflammation of the skin, accompanied by severe pruritus. Immune system dysregulation and skin barrier defects are associated with the abnormalities in atopic ...
• Combined Effects of Shear Stress and Glucose on the Morphology, Actin Filaments, and VE-Cadherin of Endothelial Cells in Vitro 

  Sulistyowati, Erna; Permatasari, Nur; Widodo, M Aris (Elsevier, 2017-06-07)

  Objective: The purpose of the present study was to analyze the effects of glucose and shear stress on the morphol ogy and density of endothelial cells, actin filamen, and the expression of VE-cadherin. Methods: After ...
• Indonesian Herbal Medicine Prevents Hypertension-Induced Left Ventricular Hypertrophy by Diminishing NADPH Oxidase-Dependent Oxidative Stress 

  Sulistyowati, Erna; Hsu, Jong-Hau; Cheng, Yuan-Bin; Chang, Fang-Rong; Cheng, Ying-Fu; Yeh, Jwu-Lai (US National Library of Medicine National Institutes of Health, 2017-09-30)

  Indonesian herbal medicine Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction (CJID) are known to be efficacious for hypertension. Oxidative stress plays an important role in hypertension-induced ...
• The Interaction of β-Glucan on Dectin-1 Receptor or TLR-2 Might Have the Potency to Activate Function of Treg Cell and Production of Anti-Inflammatory Cytokine 

  Kurniawan, Dicky; Sargowo, Djanggan; Tjokroprawiro, Askandar; Rifa'i, Muhaimin (EurAsian Journal of BioSciences, 2020-03-20)

  Objectives: Atherosclerosis formed due to the accumulation of the fibrous tissues in the vascular wall and gradually become thrombus. Agaricus brasiliensis known as a traditional drug for lifestylerelated diseases, including ...
• The Prophylactic Effects of Pomegranate Peel in a Rat Model of Rheumatoid Arthritis: Study on Arthritis Score and Expression of Inflammatory Markers 

  Wahyuningsih, Doti; Amalia, Annisa; Amiruddin, Meilano Setiawan; Cahyaningrum, Asri; Kurniasari, Laili Chintianur (Jurnal Universitas Brawijaya, 2020)

  Rheumatoid arthritis (RA) is a joint disease, chronically cause permanent joint impairment leading to inability of daily life activities. Early diagnosis and preven tive managements of RA are recommended to overcome the ...
• The Potency of Soursop Leaf Water Extract on Activating GLP-1R, Inhibiting DPP4 And FoxO1 Protein Based on in Silico Analysis 

  Damayanti, Dini Sri; Nurdiana; Kusuma, Chandra; Soeadmadji, Djoko Wahono (International Journal of Applied Pharmaceutics, 2019-12-15)

  Objective: Soursop leaf contains alkaloids, terpenoids, flavonoids, acetogenin, and phenolics. Soursop leaf decoction is usually consumed as an anti obesity agent, even though its active compounds and its action mechanism ...
• Study of Superoxide Dismutase and Malondialdehyde Concentrations in Mice After Administration of Methanolic Extract of Scurrula Atropurpurea (BL.) 

  Athiro, Nour; Wahyuningsih, Doti (Fakultas Kedokteran Hewan, Universitas Syiah Kuala, 2017-03)

  The aim of this research was to investigate the potential effect of methanolic extract of Scurrula atropurpurea (MESA) in reducing oxidative stress through observation of superoxide dismutase (SOD) activity and malondialdehyde ...
• Perbedaan Ekspresi Protein Cyclin D1 antara Adenoma dan Adenokarsinoma Kolorektal, serta Korelasinya dengan Grading dan Stadium Tumor 

  Rosidah, Aris; Norahmawati, Eviana; Anita, Kenty Wanty; Rasyid, Harun Al (Fakultas Kedokteran Universitas Brawijaya, 2020-03-20)

  Sebagian besar karsinoma kolorektal adalah adenokarsinoma, dan lebih dari 95% karsinoma kolorektal diawali oleh lesi prekursor yaitu adenoma. Risiko suatu adenoma berubah menjadi suatu karsinoma akan lebih tinggi pada ...
• Korelasi IgE Terhadap Rasio Neutrofil/Eosinofil Jaringan dan Darah Penderita Rinosinusitis Kronik Aspergillus Fumigatus 

  Duhitatrissari, Fifin Pradina; Retnoningsih, Endang; Maharani, Iriana (Oto Rhino Laryngologica Indonesiana, 2018-06-01)

  Latar Belakang: Prevalensi rinosinusitis kronik (RSK) jamur saat ini cenderung meningkat. Jamur berperan sebagai mikroorganisme dan merupakan salah satu penyebab RSK. Pemeriksaan immunoglobulin E (IgE) Aspergillus ...
• Profile of Patients with Floaters in Saiful Anwar Hospital Malang 

  Hidayah, Fenti Kusumawardhani; Dewi, Nadia Artha; Refa, Safaruddin (Indonesian Vitreoretinal Society, 2018-08-24)

  Introduction: To report the profile of patients with floaters as a subjective complain in Saiful Anwar Hospital from July 2012 until June 2013. Methods: an observasional descriptive study was conducted, collecting data ...
• Metode Slow Sand Filter dan Pengukuran MPN Coliform Sebagai Upaya Peningkatan Kualitas Air Sungai di Pekapuran Raya Banjarmasin 

  Herlina, Sri (Faculty of Medical and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, 2018)

  Sungai Pekapuran Raya Banjarmasin merupakan salah satu kawasan pinggiran sungai yang padat penduduk, saat musim kemarau kondisi sungai terlihat dangkal dipenuhi tumpukan sampah, berwarna kecoklatan dan keruh. Penelitian ...
• KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO–cGMP–MAPK Signaling Pathways 

  Lee, Meng-Luen; Sulistyowati, Erna; Hsu, Jong-Hau; Huang, Bo-Yau; Dai, Zen-Kong; Wu, Bin-Nan; Chao, Yu-Ying; Yeh, Jwu-Lai (MDPI journals, 2019-04-08)

  To test whether KMUP-1 (7-[2-[4-(2-chlorophenyl) piperazinyl]ethyl]-1,3-dimethylxanthine) prevents myocardial ischemia-induced apoptosis, we examined KMUP-1-treated H9c2 cells culture. Recent attention has focused on the ...
• The Effect of Darapladib Therapy for the Expression of Lp-PLA2 in Dyslipidemia and Type 2 Diabetes Mellitus Atherosclerosis Model 

  Wihastuti, Titin Andri; Lestari, Rosaria Dian; Heriansyah, Teuku (Journal of Applied Pharmaceutical Science, 2018-04-29)

  Atherosclerosis is the main cause of mortality and morbidity globally. Lipoprotein-associated phospholipase A2 (LpPLA2 ) activity is suspected to have a significant role in atherosclerosis. 50 Sprague-Dawley Rats were ...
• Comparison of DNA Extraction Methods Between Conventional, Kit, Alkali and Buffer-Only for PCR Amplification on Raw and Boiled Bovine and Porcine Meat 

  Yahya, Arif; Firmansyah, Marindra; Arlisyah, Annisa; Risandiansyah, Rio (Universitas Brawijaya, 2017)

  Detection of porcine contamination in food material by employing PCR techniques is integral in halal food confirmation. However, PCR is both costly and laborious, particularly in DNA isolation method. This study explores ...
• Exogenous Heat Shock Cognate Protein 70 Suppresses LPS-Induced Inflammation by Down-Regulating NF-κB through MAPK and MMP-2/-9 Pathways in Macrophages 

  Sulistyowati, Erna; Lee, Mei-Yueh; Wu, Lin-Chi; Hsu, Jong-Hau; Dai, Zen-Kong; Wu, Bin-Nan; Lin, Ming-Chung; Yeh, Jwu-Lai (MDPI journals, 2018-08-23)

  Heat shock cognate protein 70 (HSC70), a molecular chaperone, is constitutively expressed by mammalian cells to regulate various cellular functions. It is associated with many diseases and is a potential therapeutic ...
• Inhibition of Neointima Hyperplasia, Inflammation, and Reactive Oxygen Species in Balloon-Injured Arteries by HVJ Envelope Vector-Mediated Delivery of Superoxide Dismutase Gene 

  Lin, Shao-Lin; Yeh, Jwu-Lai; Chang, Tsung-Hsien; Huang, Wei-Chun; Lee, Song-Tay; Wassler, Michael; Geng, Yong-Jian; Sulistyowati, Erna (Springer, 2018-09-06)

  Extracellular superoxide dismutase (EC-SOD) has been implicated in regulation of vascular function but its underlying molecular mechanism is largely unknown. These two-step experiments investigate whether hemagglutinating ...
• Lp-PLA2 Selective Inhibitor (Darapladib) Effect In Lowering The Expression Level Of IL-1B And IL-6 In The Renal At Type 2 Diabetes Mellitus 

  Wihastuti, Titin Andri; Aini, Fitria Nugraha; Tjahjono, Cholid Tri; Sulfia, Yuni Hendrati; Sholichah, Zuhrotus; Heriansyah, Teuku (US National Library of Medicine National Institutes of Health, 2019-11-01)

  Purpose The aim of this study is to prove that type 2 diabetes mellitus can induce increasing inflammation marker in renal and that the provision of darapladib as Lp-LA2 Inhibitor agents can inhibit inflammation that were ...

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