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| dc.contributor.author | Wihastuti, Titin Andri | |
| dc.contributor.author | Aini, Fitria Nugraha | |
| dc.contributor.author | Tjahjono, Cholid Tri | |
| dc.contributor.author | Heriansyah, Teuku | |
| dc.date.accessioned | 2021-10-13T04:09:52Z | |
| dc.date.available | 2021-10-13T04:09:52Z | |
| dc.date.issued | 2019-10-10 | |
| dc.identifier.issn | 3158–3163 | |
| dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953934/ | |
| dc.identifier.uri | http://repository.unisma.ac.id/handle/123456789/2024 | |
| dc.description | [ARCHIVES] Copyright Article from: Macedonian Journal of Medical Sciences (US National Library of Medicine National Institutes of Health) | en_US |
| dc.description.abstract | BACKGROUND: High-fat diet (HFD) is associated with dyslipidemia which is a risk factor for atherosclerosis. Dyslipidemia causes oxidative stress which induces vascular cell adhesion molecule-1 (VCAM-1). Oxidative stress also triggers the thickening of tunica intima-media (IMT) and Perivascular Adipose Tissue (PVAT). Xanthone compound in ethanolic extract of Mangosteen pericarp (EEMP) has an antioxidant property to overcome the oxidative stress. AIM: The objective of this study is to investigate the effect of dietary EEMP administration on the expression of VCAM-1 and thickness of PVAT and IMT in atherosclerotic rat model fed with HFD. METHODS: This experimental laboratory study uses 25 Wistar strain Rattus norvegicus which were divided into 5 study groups. Negative Control group (GT1) was given a normal diet, Positive Control group (GT2) was treated with HFD, and three treatment groups were each treated with HFD with Mangosteen pericarp extract of 200 mg/kg BW (GT3), 400 mg/kg BW (GT4), and 800 mg/kg BW (GT5). Measurements of VCAM-1 expression were performed using immunofluorescence. PVAT and IMT measurements were performed on rat aortic preparations. RESULTS: One-way ANOVA test showed the addition of dietary EEMP significantly (p < 0.05) decreased the expression of VCAM-1 and decreased the thickness of PVAT and IMT in treatment groups as compared with both negative and positive controls. Tukey HSD test showed a dose of 800 mg/kg BW was the most effective dose for decreasing VCAM-1 level, PVAT and IMT. CONCLUSION: Dietary EEMP significantly decreases the expression of VCAM-1, as well as the thickness of PVAT and IMT in Wistar strain Rattus norvegicus treated with HFD. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | US National Library of Medicine National Institutes of Health | en_US |
| dc.relation.ispartofseries | Macedonian Journal of Medical Sciences;Vol.7, Issue 19, Page 3158-3163 | |
| dc.subject | Atherosclerosis | en_US |
| dc.subject | Dyslipidemia | en_US |
| dc.subject | Mangosteen Pericarp Ethanolic Extract | en_US |
| dc.subject | VCAM-1 | en_US |
| dc.subject | PVAT | en_US |
| dc.subject | IMT | en_US |
| dc.title | Dietary Ethanolic Extract of Mangosteen pericarp Reduces VCAM-1, Perivascular Adipose Tissue and Aortic Intimal Medial Thickness in Hypercholesterolemic Rat Model | en_US |
| dc.type | Article | en_US |
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Publikasi Ilmiah Dosen Program Studi Pendidikan Dokter