In Silico Study to Assess Antibacterial Activity from Cladophora Sp. on Peptide Deformylase: Molecular Docking Approach

Show simple item record

dc.contributor.author Bintari, Yoni Rina
dc.contributor.author Risandiansyah, Rio
dc.date.accessioned 2021-10-13T04:12:19Z
dc.date.available 2021-10-13T04:12:19Z
dc.date.issued 2019-05-04
dc.identifier.issn 2621-4814
dc.identifier.uri http://journal.umpalangkaraya.ac.id/index.php/bjop/article/view/717
dc.identifier.uri http://repository.unisma.ac.id/handle/123456789/2025
dc.description [ARCHIVES] Copyright Article from: Borneo Journal of Pharmacy (Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya) en_US
dc.description.abstract Increasing antibiotic-resistant pathogenic bacteria is a severe problem in the world. Therefore, there is a need to identify new drugs from natural products and also new drug targets. Cladophora sp. is a marine organism which is known to have bioactive compounds and a potential antibacterial. On the other hand, Peptide Deformylase (PDf) may prove to be a novel drug target since it is crucial for native peptide functioning in most pathogenic bacteria. This study screens for PDf inhibition activity of compounds from Cladophora sp. using molecular docking approach and screening the binding affinity of bioactive compounds against the peptide receptor PDf using Pyrex Autodock Vina software. Docking results were stored and visualized using Biovia Discovery Studio and PyMOL ligand. Ligands were obtained from previous literature in PubChem, and receptor peptide PDf from pathogenic bacteria: Pseudomonas aeruginosa (PDB ID:1N5N), Escherichia coli (PDB ID:1BSK), Enterococcus faecium (PDB ID:3G6N) and Staphylococcus aureus (PDB ID:1LQW), was obtained from the peptide data bank. The results of this screening show with ligand the highest binding affinity against PDf of P. aeruginosa, E. coli, E. faecium, and S. aureus is stearic acid (-5.9 kcal/mol), eicosapentaenoic acid (-6.6 kcal/mol), stearic acid (-5.8 kcal/mol), and stearic acid (-6.2 kcal/mol) respectively. The binding of natural compounds from Cladophora sp. with PDf models may provide a new drug with a different drug target for antibacterial potential. en_US
dc.language.iso en en_US
dc.publisher Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya en_US
dc.relation.ispartofseries Borneo Journal of Pharmacy;Vol.2, Issue 1, Pages 20-23
dc.subject In silico en_US
dc.subject Antibacterial en_US
dc.subject Cladophora sp en_US
dc.subject Peptide Deformilase en_US
dc.title In Silico Study to Assess Antibacterial Activity from Cladophora Sp. on Peptide Deformylase: Molecular Docking Approach en_US
dc.type Article en_US


Files in this item

Icon
Name: Bu Yoni-1- document ...
Size: 139.3Kb
Format: PDF
Description: Document
View/Open

This item appears in the following Collection(s)

Show simple item record

Kolom Pencarian


Browse

My Account