Anti-Inflammatory Activity of Agaricus Blazei Murill Extract In The Spleen of Mice Fed a High-Fat Diet

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dc.contributor.author Kurniawan, Dicky
dc.contributor.author Sargowo, Djanggan
dc.contributor.author Tjokroprawiro, Askandar
dc.contributor.author Rifa'i, Muhaimin
dc.date.accessioned 2021-10-13T04:14:30Z
dc.date.available 2021-10-13T04:14:30Z
dc.date.issued 2018-03-31
dc.identifier.issn 1596-9827
dc.identifier.uri https://www.tjpr.org/home/abstract.php?id=2087&aTitle=Anti-inflammatory%20activity%20of%20Agaricus%20blazei%20Murill%20extract%20in%20the%20spleen%20of%20mice%20fed%20a%20high-fat%20diet
dc.identifier.uri http://repository.unisma.ac.id/handle/123456789/2026
dc.description [ARCHIVES] Copyright Article from: Tropical Journal of Pharmaceitical Research (Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria) en_US
dc.description.abstract urpose: To examine the effects of A. blazei Murill on the production of proinflammatory cytokine TNF-α and regulatory cytokine IL-10 in the spleen of mice fed a high-fat diet. Methods: The study was conducted on 25 BALB/c male mice divided into five groups consisting of five mice in each group and utilized three A. blazei Murill extract doses: 100, 200 and 400 mg/kg. The mice were fed a high-fat diet (HFD) and given A. blazei Murill extract for 12 weeks. The relative number of CD4+TNF-α+, CD11b/c+TNF-α+, and CD4+CD25+IL-10+ were measured using flow cytometry. Results: Oral administration of A. blazei Murill extract (100 mg/kg) in mice fed a high-fat diet significantly decreased (p < 0.05) the level of TNF-α that produced by CD4+ T cells and macrophages (1.64 %), compared with control. The 200 mg/kg dose decreased the level of CD11b/c+TNF-α+ by 5.37 % (p < 0.05) compared to 100 mg/kg dose. The 400 mg/kg dose significantly enhanced regulatory cytokines IL-10 by 17.56 % (p < 0.05) in mice fed a high-fat diet. Conclusion: This findings suggest that Agaricus blazei Murill can inhibits processes in HFD-induced mice by reducing TNF-α production and increasing the anti-inflammatory cytokine IL-10. These results provide new insight into the pharmacological actions of Agaricus blazei Murill as a medicinal food for potential therapy of atherosclerosis disease en_US
dc.language.iso en en_US
dc.publisher Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria en_US
dc.relation.ispartofseries Tropical Journal of Pharmaceutical Research;Vol.17, Issue 3, Page 483-489
dc.subject Anti-inflammatory agent en_US
dc.subject Agaricus blazei Murill en_US
dc.subject Proinflammatory cytokine en_US
dc.subject TNF-α en_US
dc.subject IL-10 en_US
dc.title Anti-Inflammatory Activity of Agaricus Blazei Murill Extract In The Spleen of Mice Fed a High-Fat Diet en_US
dc.type Article en_US


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