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| dc.contributor.author | Kurniawan, Dicky | |
| dc.contributor.author | Sargowo, Djanggan | |
| dc.contributor.author | Tjokroprawiro, Askandar | |
| dc.contributor.author | Rifa'i, Muhaimin | |
| dc.date.accessioned | 2021-10-13T04:14:30Z | |
| dc.date.available | 2021-10-13T04:14:30Z | |
| dc.date.issued | 2018-03-31 | |
| dc.identifier.issn | 1596-9827 | |
| dc.identifier.uri | https://www.tjpr.org/home/abstract.php?id=2087&aTitle=Anti-inflammatory%20activity%20of%20Agaricus%20blazei%20Murill%20extract%20in%20the%20spleen%20of%20mice%20fed%20a%20high-fat%20diet | |
| dc.identifier.uri | http://repository.unisma.ac.id/handle/123456789/2026 | |
| dc.description | [ARCHIVES] Copyright Article from: Tropical Journal of Pharmaceitical Research (Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria) | en_US |
| dc.description.abstract | urpose: To examine the effects of A. blazei Murill on the production of proinflammatory cytokine TNF-α and regulatory cytokine IL-10 in the spleen of mice fed a high-fat diet. Methods: The study was conducted on 25 BALB/c male mice divided into five groups consisting of five mice in each group and utilized three A. blazei Murill extract doses: 100, 200 and 400 mg/kg. The mice were fed a high-fat diet (HFD) and given A. blazei Murill extract for 12 weeks. The relative number of CD4+TNF-α+, CD11b/c+TNF-α+, and CD4+CD25+IL-10+ were measured using flow cytometry. Results: Oral administration of A. blazei Murill extract (100 mg/kg) in mice fed a high-fat diet significantly decreased (p < 0.05) the level of TNF-α that produced by CD4+ T cells and macrophages (1.64 %), compared with control. The 200 mg/kg dose decreased the level of CD11b/c+TNF-α+ by 5.37 % (p < 0.05) compared to 100 mg/kg dose. The 400 mg/kg dose significantly enhanced regulatory cytokines IL-10 by 17.56 % (p < 0.05) in mice fed a high-fat diet. Conclusion: This findings suggest that Agaricus blazei Murill can inhibits processes in HFD-induced mice by reducing TNF-α production and increasing the anti-inflammatory cytokine IL-10. These results provide new insight into the pharmacological actions of Agaricus blazei Murill as a medicinal food for potential therapy of atherosclerosis disease | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria | en_US |
| dc.relation.ispartofseries | Tropical Journal of Pharmaceutical Research;Vol.17, Issue 3, Page 483-489 | |
| dc.subject | Anti-inflammatory agent | en_US |
| dc.subject | Agaricus blazei Murill | en_US |
| dc.subject | Proinflammatory cytokine | en_US |
| dc.subject | TNF-α | en_US |
| dc.subject | IL-10 | en_US |
| dc.title | Anti-Inflammatory Activity of Agaricus Blazei Murill Extract In The Spleen of Mice Fed a High-Fat Diet | en_US |
| dc.type | Article | en_US |
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