Association of LL-37 and IL-31 Serum Levels with SCORing Atopic Dermatitis (SCORAD) Score in Atopic Dermatitis Patients

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dc.contributor.author Brahmanti, Herwinda
dc.contributor.author Rofiq, Aunur
dc.contributor.author Cholis, Moch
dc.contributor.author Trijayanti, Unundya
dc.contributor.author Purwanti, Sasi
dc.date.accessioned 2021-10-14T03:09:39Z
dc.date.available 2021-10-14T03:09:39Z
dc.date.issued 2018-05-12
dc.identifier.uri http://www.iranjd.ir/article_99302.html
dc.identifier.uri http://repository.unisma.ac.id/handle/123456789/2049
dc.description [ARCHIVES] Copyright Article from: Iranian Journal of Dermatology en_US
dc.description.abstract Background: Atopic dermatitis is a chronic, recurrent inflammation of the skin, accompanied by severe pruritus. Immune system dysregulation and skin barrier defects are associated with the abnormalities in atopic dermatitis. Myriad pieces of evidence have pointed to the major roles of LL-37 and interleukin-31 (IL31) in atopic dermatitis. The studies on atopic dermatitis are still limited in Indonesia, particularly in Malang city. The objective of the present study was to understand the association of LL-37 and IL-31 serum levels with SCORing Atopic Dermatitis (SCORAD) in atopic dermatitis patients. Methods: The present research is an analytical observational cross-sectional study with 30 atopic dermatitis patients as subjects. Through a consecutive sampling method, samples were collected from the outpatient clinics of dermatovenereology and pediatric department, Dr. Saiful Anwar General Hospital (RSSA), Malang, Indonesia. LL-37 and IL-31 serum levels were examined via Enzyme-Linked Immunosorbent Assay (ELISA) method. Subjects were allocated into two groups of atopic dermatitis severity, mild and moderate-severe, based on the SCORAD index. Results: Based on the Pearson correlation test, there was no correlation between LL-37 serum level, IL-31 serum level and the SCORAD score (r=-0.238 with P=0.205, and r=0.15 with P=0.939). Conclusion: LL-37 and IL-31 serum levels are not associated with atopic dermatitis severity. en_US
dc.language.iso en en_US
dc.publisher Iranian Journal of Dermatology en_US
dc.relation.ispartofseries Iranian Journal of Dermatology;Vol.2, Issue 1, Page 7-13
dc.subject Atopic Dermatitis en_US
dc.subject Interleukin-31 en_US
dc.subject LL-37 en_US
dc.subject Scoring of Atopic Dermatitis en_US
dc.title Association of LL-37 and IL-31 Serum Levels with SCORing Atopic Dermatitis (SCORAD) Score in Atopic Dermatitis Patients en_US
dc.type Article en_US


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