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| dc.contributor.author | Sulistyowati, Erna | |
| dc.contributor.author | Jan, Ren-Long | |
| dc.contributor.author | Liou, Shu-Fen | |
| dc.contributor.author | Chen, Ying-Fu | |
| dc.contributor.author | Wu, Bin-Nan | |
| dc.contributor.author | Hsu, Jong-Hau | |
| dc.contributor.author | Yeh, Jwu-Lai | |
| dc.date.accessioned | 2021-10-14T03:12:29Z | |
| dc.date.available | 2021-10-14T03:12:29Z | |
| dc.date.issued | 2019-06-24 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S2225411018309702 | |
| dc.identifier.uri | http://repository.unisma.ac.id/handle/123456789/2050 | |
| dc.description | [ARCHIVES] Copyright Article from: Journal of Traditional and Complementary Medicine | en_US |
| dc.description.abstract | Background and aim: Centella asiatica,Justicia gendarussaandImperata cylindricadecoction (CJID) isefficacious for hypertension. NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX)-induced reactive oxygen species (ROS) generation modulates nuclear factor kappa B (NF-kB) activationand thus mediates hypertension-induced vascular remodeling. This research aims to investigate the anti-remodeling effect of CJID through the mechanism of NOXs-ROS-NF-kB pathway in spontaneously hy-pertensive rats (SHRs).Experimental procedure:CJID was orally administered once a day forfive weeks in SHRs andnormotensive-WKY (Wistar Kyoto) rats. All rats were sacrificed at the end of study and different assayswere performed to determine whether CJID ameliorates vascular remodeling in SHRs, such as histo-logical examination; lactate dehydrogenase (LDH), nitric oxide (NO), malondialdehyde (MDA) and su-peroxide dismutase (SOD) assays; superoxide and hydrogen peroxide (H2O2) generation assays,immunohistochemistry and immunofluorescence assays. . Changes in levels of inducible nitric oxidesynthase (iNOS), NF-kB-p65, NF-kB inhibitor alpha/IkBa(inhibitory kappa B- alpha), phosphorylation ofIkBa(p-IkBa) and NOX1, NOX2, NOX4 in the thoracic aorta were determined.Results:Vascular remodeling indicators, media thickness, collagen and elastic accumulation in thethoracic aorta, of SHRs-treated CJID were attenuated. Redox homeostasis, aortic superoxide andhydrogen peroxide generation were decreased in SHRs-treated group. Aortic iNOS, p-IkBa, NF-kB-p65and NOX1, NOX2, NOX4 expressions were suppressed. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.ispartofseries | Journal of Traditional and Complementary Medicine;Vol.10, Issue 4, Page 378-388 | |
| dc.subject | Indonesian herbal medicine | en_US |
| dc.subject | Vascular remodeling | en_US |
| dc.subject | Oxidative stress | en_US |
| dc.subject | Hypertension | en_US |
| dc.title | Vasculoprotective Effects of Centella Asiatica, Justicia Gendarussa and Imperata Cylindrica Decoction via the NOXs-ROS-NF-κB Pathway in Spontaneously Hypertensive Rats | en_US |
| dc.type | Article | en_US |
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Publikasi Ilmiah Dosen Program Studi Pendidikan Dokter