Molecular Docking of Soybean (Glycine max) Seed and Ginger (Zingiber officinale) Rhizome Components as Anti-Diabetic Through Inhibition of Dipeptidyl Peptidase 4 (DPP-4) and Alpha-Glucosidase Enzymes

Purnomo, Yudi; Taufiq, Muhammad; Wijaya, Afnan N. D.; Hakim, Reza

dc.contributor.author	Purnomo, Yudi
dc.contributor.author	Taufiq, Muhammad
dc.contributor.author	Wijaya, Afnan N. D.
dc.contributor.author	Hakim, Reza
dc.date.accessioned	2023-01-10T02:46:23Z
dc.date.available	2023-01-10T02:46:23Z
dc.date.issued	2021-10-01
dc.identifier.citation	Purnomo, Y., Taufiq, M., N. D. Wijaya, A., & Hakim, R. (2021). Molecular Docking of Soybean (Glycine max) Seed and Ginger (Zingiber officinale) Rhizome Components as Anti-Diabetic Through Inhibition of Dipeptidyl Peptidase 4 (DPP-4) and Alpha-Glucosidase Enzymes: doi.org/10.26538/tjnpr/v5i10.7. Tropical Journal of Natural Product Research (TJNPR), 5(10), 1735–1742. Retrieved from https://www.tjnpr.org/index.php/home/article/view/374	en_US
dc.identifier.issn	2616-0692
dc.identifier.uri	https://www.tjnpr.org/index.php/home/article/view/374
dc.identifier.uri	http://repository.unisma.ac.id/handle/123456789/6190
dc.description	[ARCHIVES] Copyright Article From:Tropical Journal of Natural Product Research (TJNPR)	en_US
dc.description.abstract	Dipeptidyl Peptidase-4 (DPP-4) and alpha-glucosidase (α-glucosidase) are enzymes involved in carbohydrate metabolism. Inhibition of these enzymes contribute to blood glucose level suppression. Soybean (Glycine max) seeds and ginger (Zingiber officinale) rhizome are herbs that have anti-diabetic activity. The mechanism of action, however, has not been thoroughly explored. This study aims to evaluate the anti-diabetic potentials of the chemical components in soybean seeds and ginger rhizome through inhibition activity of DPP-4 and α-glucosidase in silico. Soybean seed and ginger rhizome were extracted using the maceration method with ethanol solvent. Ethanol extract of soybean seeds and ginger rhizome were analysed using Liquid Chromatography-Mass Spectrometry (LC-MS/MS). The potency of active compounds from the plants on DPP-4 and α-glucosidase were evaluated by in silico study using web-based software (Docking server). Soybean seed were found to contain phytosterols, mainly beta sitosterol, campesterol, stigmasterol, and lanosterol. Meanwhile, ginger rhizome was found to contain 6-gingerdiol, 10-gingerol and 12-shogaol. Molecular docking study showed that stigmasterol and 12-shogaol strongly inhibits DPP-4 activity while stigmasterol and 6-Gingerdiol strongly inhibited α-glucosidase. This shows that both soybean seed and ginger rhizome potentially act as an anti-diabetic by inhibiting DPP-4 and α-glucosidase; however, soybean seed is more potent due to its ability to inhibit both of the tested enzymes.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Tropical Journal of Natural Product Research	en_US
dc.relation.ispartofseries	Tropical Journal of Natural Product Research;Vol 5, No 10
dc.subject	Anti-diabetic	en_US
dc.subject	Glycine	en_US
dc.subject	DPP-4	en_US
dc.subject	α-glucosidase	en_US
dc.title	Molecular Docking of Soybean (Glycine max) Seed and Ginger (Zingiber officinale) Rhizome Components as Anti-Diabetic Through Inhibition of Dipeptidyl Peptidase 4 (DPP-4) and Alpha-Glucosidase Enzymes	en_US
dc.type	Article	en_US