dc.contributor.author |
Purnomo, Yudi |
|
dc.contributor.author |
Soeatmadji, D.W |
|
dc.contributor.author |
Sumitro, S.B |
|
dc.contributor.author |
Widodo, M.A |
|
dc.date.accessioned |
2023-01-18T16:08:21Z |
|
dc.date.available |
2023-01-18T16:08:21Z |
|
dc.date.issued |
2015-01-19 |
|
dc.identifier.issn |
0975-4873 |
|
dc.identifier.uri |
http://impactfactor.org/PDF/IJPPR/7/IJPPR,Vol7,Issue5,Article33.pdf |
|
dc.identifier.uri |
http://repository.unisma.ac.id/handle/123456789/6323 |
|
dc.description |
[ARCHIVES] Copyright Article from: International Journal of Pharmacognosy and Phytochemical Research 2015; 7(5); 1073-1079 |
en_US |
dc.description.abstract |
Glucagon Like Peptide-1 (GLP-1) is one of incretin hormone which is proposed as a new therapy for type 2 diabetes
(T2DM). However, this hormone is metabolized excessively by Dipeptidyl Peptidase IV (DPP-IV) into inactive form.
The inhibition of DPP-IV can prolong GLP-1 bioavailability for regulating blood glucose level on T2DM. Urena lobata
is a plant which has been used to cure T2DM empirically but the inhibitory activity on DPP-IV has not been tested. The
aim of the study was to evaluate anti diabetic effect of U. lobata leaf extract through DPP-IV inhibition. Urena lobata
leaf was extracted in ethanol solvent and hot water then evaporated till pasta form. The object study was used animal
model of T2DM which divided into 2 control group and 6 test group (n=4) and then DPP-IV level, GLP-1, insulin and
blood glucose AUC were examined after supplemented U. lobata leaf extract. All data are expressed as the mean ± SD
and analyzed with one way anova and then continued with LSD and Dunnet c (p<0.05). Both of water and ethanolic
extract from U. lobata decrease DPP-IV level and blood glucose AUC compared to control group (p<0.05) whereas
insulin level and GLP-1 are increased (p<0.05). It was controlled by stigmasterol, β-sitosterol and mangiferin having
anti-diabetic effect by inhibiting DPP-IV. Water extract of U. lobata stronger decrease DPP-IV level and blood glucose
AUC and also increase insulin level and GLP-1 compared to ethanolic extract (p<0.05). The conformation change of
active substances result a poor solubility and absorption in ethanol extract contribute to decrease their biology activity. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
International Journal of Pharmacognosy and Phytochemical research (IJPPR) |
en_US |
dc.relation.ispartofseries |
International Journal of Pharmacognosy and Phytochemical Research 2015;7(5); 1073-1079 |
|
dc.subject |
Diabetes mellitus type II |
en_US |
dc.subject |
DPP-IV |
en_US |
dc.subject |
GLP-1 |
en_US |
dc.subject |
Insulin |
en_US |
dc.subject |
Urena lobata |
en_US |
dc.title |
Anti-hiperglycemic Effect of Urena lobata Leaf Extract by Inhibition of Dipeptidyl Peptidase IV ( DPP-IV ) on Diabetic Rats |
en_US |
dc.type |
Article |
en_US |