Browsing LP - Faculty of Medicine by Author "Kusuma, Chandra"

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Effects of Soursop (Annona muricata ) Leaf Water Extract (SLWE) on Body Weight, Leptin and TNF α Plasma Levels of Rats with High Fat and High Fructose (HFHF) Diet.

Damayanti, Dini Sri; Kusuma, Chandra; Nurdiana; Soeadmadji, Djoko Wahono (Journal of Global Pharma Technology, 2019-04)

Background: Soursop leaves believed to be able to lose weight. The aim of the study was to prove that SLWE had an effect on body weight, leptin and TNF α plasma level in mice with the HFHF diet . Methods:The study used ...
The Potency of Soursop Leaf Water Extract on Activating GLP-1R, Inhibiting DPP4 And FoxO1 Protein Based on in Silico Analysis

Damayanti, Dini Sri; Nurdiana; Kusuma, Chandra; Soeadmadji, Djoko Wahono (International Journal of Applied Pharmaceutics, 2019-12-15)

Objective: Soursop leaf contains alkaloids, terpenoids, flavonoids, acetogenin, and phenolics. Soursop leaf decoction is usually consumed as an anti obesity agent, even though its active compounds and its action mechanism ...
Revealing The Potency of Annona Muricata Leaves Extract as FOXO1 Inhibitor for Diabetes Mellitus Treatment Through Computational Study

Damayanti, Dini Sri; Utomo, Didik Huswo; Kusuma, Chandra (Springer, 2017-06-26)

FOXO1 protein inactivation in the nucleus is one of targets for the treatment of diabetes mellitus. Annona muricata leaves contain flavonoid and phenolic compound alkaloids that were known to be able to increase pancreatic ...

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