Browsing LP - Faculty of Medicine by Subject "VDR knockout"

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Both ligand and VDR expression levels critically determine the effect of 1α,25-dihydroxyvitamin-D3 on osteoblast differentiation

Yang, Dongqing; Anderson, Paul H.; Wijeyanaka, Asiri R.; Barratt, Kate R.; Triliana, Rahma; Stapledon, Catherine J.M.; Zhou, Hong; Findlay, David M.; Morris, Howard A.; Atkins, Gerald J. (Elsevier, 2018)

Previous studies have shown that 1α,25-dihydroxyvitamin D3 (1,25D) through vitamin D receptor (VDR) signalling has both catabolic and anabolic effects on osteoblast differentiation. However, the mechanism of these differential ...