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Dietary Ethanolic Extract of Mangosteen pericarp Reduces VCAM-1, Perivascular Adipose Tissue and Aortic Intimal Medial Thickness in Hypercholesterolemic Rat Model
(US National Library of Medicine National Institutes of Health, 2019-10-10)
BACKGROUND:
High-fat diet (HFD) is associated with dyslipidemia which is a risk factor for atherosclerosis. Dyslipidemia causes oxidative stress which induces vascular cell adhesion molecule-1 (VCAM-1). Oxidative stress ...
Lp-PLA2 Selective Inhibitor (Darapladib) Effect In Lowering The Expression Level Of IL-1B And IL-6 In The Renal At Type 2 Diabetes Mellitus
(US National Library of Medicine National Institutes of Health, 2019-11-01)
Purpose
The aim of this study is to prove that type 2 diabetes mellitus can induce increasing inflammation marker in renal and that the provision of darapladib as Lp-LA2 Inhibitor agents can inhibit inflammation that were ...
The Effect of Darapladib Therapy for the Expression of Lp-PLA2 in Dyslipidemia and Type 2 Diabetes Mellitus Atherosclerosis Model
(Journal of Applied Pharmaceutical Science, 2018-04-29)
Atherosclerosis is the main cause of mortality and morbidity globally. Lipoprotein-associated phospholipase A2
(LpPLA2
) activity is suspected to have a significant role in atherosclerosis. 50 Sprague-Dawley Rats were ...