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Indonesian Herbal Medicine Prevents Hypertension-Induced Left Ventricular Hypertrophy by Diminishing NADPH Oxidase-Dependent Oxidative Stress
(US National Library of Medicine National Institutes of Health, 2017-09-30)
Indonesian herbal medicine Centella asiatica, Justicia gendarussa and
Imperata cylindrica decoction (CJID) are known to be efficacious for hypertension.
Oxidative stress plays an important role in hypertension-induced ...
Exogenous Heat Shock Cognate Protein 70 Suppresses LPS-Induced Inflammation by Down-Regulating NF-κB through MAPK and MMP-2/-9 Pathways in Macrophages
(MDPI journals, 2018-08-23)
Heat shock cognate protein 70 (HSC70), a molecular chaperone, is constitutively
expressed by mammalian cells to regulate various cellular functions. It is associated with
many diseases and is a potential therapeutic ...
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D3 Plus Nicotine
(MDPI journals, 2020-10-06)
Vascular calcification (VC) is highly prevalent in patients with atherosclerosis, chronic kidney disease, diabetes mellitus, and hypertension. In blood vessels, VC is associated with major adverse cardiovascular events. ...
Inhibition of Neointima Hyperplasia, Inflammation, and Reactive Oxygen Species in Balloon-Injured Arteries by HVJ Envelope Vector-Mediated Delivery of Superoxide Dismutase Gene
(Springer, 2018-09-06)
Extracellular superoxide dismutase (EC-SOD) has been implicated in regulation of vascular function but its underlying molecular
mechanism is largely unknown. These two-step experiments investigate whether hemagglutinating ...
KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO–cGMP–MAPK Signaling Pathways
(MDPI journals, 2019-04-08)
To test whether KMUP-1 (7-[2-[4-(2-chlorophenyl) piperazinyl]ethyl]-1,3-dimethylxanthine) prevents myocardial ischemia-induced apoptosis, we examined KMUP-1-treated H9c2 cells culture. Recent attention has focused on the ...
Vasculoprotective Effects of Centella Asiatica, Justicia Gendarussa and Imperata Cylindrica Decoction via the NOXs-ROS-NF-κB Pathway in Spontaneously Hypertensive Rats
(Elsevier, 2019-06-24)
Background and aim: Centella asiatica,Justicia gendarussaandImperata cylindricadecoction (CJID) isefficacious for hypertension. NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX)-induced reactive oxygen ...
In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis
(National Library of Medicine, 2021-05-28)
Osteoarthritis is a degenerative arthropathy that is mainly characterized by dysregulation
of inflammatory responses. KMUP-1, a derived chemical synthetic of xanthine, has been shown
to have anti-inflammatory and antioxidant ...