EFEK KOMBINASI SEFTRIAKSON DAN KLORAMFENIKOL PADA Staphylococcus aureus DARI ISOLAT GANGREN DIABETIK

Purnomo, Yudi; Chandra, Pasha; Triliana, Rahma

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dc.contributor.author	Purnomo, Yudi
dc.contributor.author	Chandra, Pasha
dc.contributor.author	Triliana, Rahma
dc.date.accessioned	2023-01-18T16:10:20Z
dc.date.available	2023-01-18T16:10:20Z
dc.date.issued	2022-03-01
dc.identifier.citation	Purnomo, Y., Chandra, P., & Triliana, R. (2022). The Combination Effect of Ceftriaxone and Chloramphenicol on Staphylococcus aureus Isolate of Diabetic Gangrene: Efek Kombinasi Seftriakson dan Kloramfenikol pada Staphylococcus aureus Isolat dari Gangren Diabetik. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 8(1), 31-40. https://doi.org/10.22487/j24428744.2022.v8.i1.15819	en_US
dc.identifier.issn	2442-8744
dc.identifier.uri	https://bestjournal.untad.ac.id/index.php/Galenika/article/view/15819
dc.identifier.uri	http://repository.unisma.ac.id/handle/123456789/6324
dc.description	[ARCHIVES] Copyright Article from: Jurnal Farmasi Galenika	en_US
dc.description.abstract	Diabetic gangrene is a complication of Diabetes mellitus caused by Staphylococcus aureus. The combination of Ceftriaxone and Chloramphenicol is often used to cure gangrene infection, even though, they produce antagonist interaction based on theory. Objectives: To evaluate the potency of Ceftriaxone, Chloramphenicol and its combination on Staphylococcus aureus isolate of Diabetic gangrene. Material and Methods: The research was done by using disc diffusion methods with Muller Hinton media. Ceftriaxone, Chloramphenicol and its combination dose of 7,5 µg/ml, 15 µg/ml and 30 µg/ml, respectively were tested on Staphylococcus aureus culture taken form the diabetic gangrene patients. Antibacterial effect was observed by measuring inhibition zone on bacteria culture. Type of interaction was analyzed by Ameri-Ziaei Double Antibiotic Synergism Test (AZDAST) method. The results of study were tested statistically with One Way ANOVA (p=0.05) followed by Least Significant Difference (LSD) test. Results: The combination of Ceftriaxone and Chloramphenicol showed an antibacterial effect lower than Ceftriaxone. ß-lactam antibiotic like Ceftriaxone require the cell be growing and dividing in order to have a bactericidal action. Meanwhile, Chloramphenicol causes a slow growth of Staphylococcus aureus and impairs bactericidal effect of Ceftriaxone if they are combined. Conclusions: Ceftriaxone and Chloramphenicol combination has lower antibacterial effect than the single antibiotic groups on Staphylococcus aureus isolate of Gangrene diabetic and the type of interaction is antagonistic.	en_US
dc.language.iso	other	en_US
dc.publisher	Jurnal Farmasi Galenika	en_US
dc.relation.ispartofseries	Jurnal Farmasi Galenika;Vol. 8 No. 1
dc.subject	Ceftriaxone	en_US
dc.subject	Chloramphenicol	en_US
dc.subject	Staphylococcus aureus isolate of Gangrene diabetic	en_US
dc.title	EFEK KOMBINASI SEFTRIAKSON DAN KLORAMFENIKOL PADA Staphylococcus aureus DARI ISOLAT GANGREN DIABETIK	en_US
dc.title.alternative	The Combination Effect of Ceftriaxone and Chloramphenicol on Staphylococcus aureus Isolate of Diabetic Gangrene	en_US
dc.type	Article	en_US