The Interaction of β-Glucan on Dectin-1 Receptor or TLR-2 Might Have the Potency to Activate Function of Treg Cell and Production of Anti-Inflammatory Cytokine

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dc.contributor.author Kurniawan, Dicky
dc.contributor.author Sargowo, Djanggan
dc.contributor.author Tjokroprawiro, Askandar
dc.contributor.author Rifa'i, Muhaimin
dc.date.accessioned 2021-10-14T02:56:31Z
dc.date.available 2021-10-14T02:56:31Z
dc.date.issued 2020-03-20
dc.identifier.uri http://www.ejobios.org/download/the-interaction-of-glucan-on-dectin-1-receptor-or-tlr-2-might-have-the-potency-to-activate-function-7581.pdf
dc.identifier.uri http://repository.unisma.ac.id/handle/123456789/2046
dc.description [ARCHIVES] Copyright Article from: EurAsian Journal of BioSciences en_US
dc.description.abstract Objectives: Atherosclerosis formed due to the accumulation of the fibrous tissues in the vascular wall and gradually become thrombus. Agaricus brasiliensis known as a traditional drug for lifestylerelated diseases, including obesity, hypertension, and diabetes. The aim of this research was to examine the potency of Agaricus brasiliensis to reduce the excessive inflammatory response that occurs in the process of atherosclerosis. The extract of Agaricus brasiliensis contains β-glucans and Agiritin that may bound to the Dectin-1 receptor and TLR-2. Methods: Therefore, we examine the interaction of the molecules by using bioinformatic. We have docked β-glucans and Agaritin to the active site of the Dectin-1 receptor and TLR-2. Results: The result of the analysis indicated the binding affinity of between TLR2/1 and 1,3-1,6 β-glucan or agaritin showed higher compared to positive control, Tri-Acylated Lipopeptide. Besides β-glucan 1,3-1,6 bound to Dectin-1 has similar binding affinity compared to the positive control, Beta-D-Glucose. Conclusions: It could be concluded that β-glucan 1,3-1,6 and agaritin might enable to activate the TLR2. However, Dectin-1 receptor might only be activated by 1,3-1,6. β-glucan. en_US
dc.language.iso en en_US
dc.publisher EurAsian Journal of BioSciences en_US
dc.relation.ispartofseries EurAsian Journal of BioSciences;
dc.subject Atherosclerosi en_US
dc.subject Agaricus Brasiliensis en_US
dc.subject β-glucan en_US
dc.subject Dectin-1 Receptor en_US
dc.subject TLR2/1 en_US
dc.title The Interaction of β-Glucan on Dectin-1 Receptor or TLR-2 Might Have the Potency to Activate Function of Treg Cell and Production of Anti-Inflammatory Cytokine en_US
dc.type Article en_US


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