Abstract:
Objectives: Atherosclerosis formed due to the accumulation of the fibrous tissues in the vascular
wall and gradually become thrombus. Agaricus brasiliensis known as a traditional drug for lifestylerelated diseases, including obesity, hypertension, and diabetes. The aim of this research was to
examine the potency of Agaricus brasiliensis to reduce the excessive inflammatory response that
occurs in the process of atherosclerosis. The extract of Agaricus brasiliensis contains β-glucans and
Agiritin that may bound to the Dectin-1 receptor and TLR-2. Methods: Therefore, we examine the
interaction of the molecules by using bioinformatic. We have docked β-glucans and Agaritin to the
active site of the Dectin-1 receptor and TLR-2. Results: The result of the analysis indicated the
binding affinity of between TLR2/1 and 1,3-1,6 β-glucan or agaritin showed higher compared to
positive control, Tri-Acylated Lipopeptide. Besides β-glucan 1,3-1,6 bound to Dectin-1 has similar
binding affinity compared to the positive control, Beta-D-Glucose. Conclusions: It could be
concluded that β-glucan 1,3-1,6 and agaritin might enable to activate the TLR2. However, Dectin-1
receptor might only be activated by 1,3-1,6. β-glucan.
