Browsing LP - Faculty of Medicine by Author "Purnomo, Yudi"

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Acute Toxicity Level of Pulutan (Urena lobata) Leaf Extract on Zebrafish (Danio rerio) and its Analysis by In Silico Study

Purnomo, Yudi; Aini, Noer; Widodo, Aris Moch (The Japanese Pharmacological Society, The Japanese Society of Clinical Pharmacology, 2018-07-06)

Pulutan (Urena lobata) is medicinal plant used to treat some diseases empirically, with pre-clinical study has already proven its efficacy, however, its safety has not been evaluated. Acute toxicity has to be performed on ...
Analisa Kelengkapan dan Kesesuaian Peresepan Pasien Rawat Jalan di Rumah Sakit Islam “X” Malang

Purnomo, Yudi; Rejeki, Wara (Journal of Pharmaceutical Care Anwar Medika (JPhAM), 2022-07-04)

Peresepan obat yang tidak rasional merupakan masalah serius dalam pelayanan kesehatandi Indonesia. Faktor yang berperan terhadap kondisi ini adalah ketidaklengkapan dan ketidaksesuaian peresepan ...
Anti-atherogenic Effects of Soybean (Glycine max) Seed and Ginger (Zingiber officinale) Rhizome Extracts on Type 2 Diabetic Rat Model

Purnomo, Yudi; Triliana, Rahma; Wibisono, Nugroho (Tropical Journal of Natural Product Research (TJNPR), 2022-05-12)

Diabetes mellitus (DM) is linked to an increase in dyslipidemia, which is associated with atherosclerosis, one of the leading causes of cardiovascular disease. Soybean(Glycine max) and ginger(Zingiber officinale) ...
Anti-diabetic potential of Urena lobata leaf extract through inhibition of dipeptidyl peptidase IV activity

Purnomo, Yudi; Soeatmadji, D.W; Sumitro, S.B; Widodo, M.A (Asian Pacific Journal of Tropical Biomedicine, 2015-08-01)

Objective To evaluate the anti-diabetic potential of leaf extract from Urena lobata (U. lobata) through dipeptidyl peptidase IV (DPP-IV) inhibitory activity. Methods U. lobata leaf was extracted in hot water and ...
Anti-hiperglycemic Effect of Urena lobata Leaf Extract by Inhibition of Dipeptidyl Peptidase IV ( DPP-IV ) on Diabetic Rats

Purnomo, Yudi; Soeatmadji, D.W; Sumitro, S.B; Widodo, M.A (International Journal of Pharmacognosy and Phytochemical research (IJPPR), 2015-01-19)

Glucagon Like Peptide-1 (GLP-1) is one of incretin hormone which is proposed as a new therapy for type 2 diabetes (T2DM). However, this hormone is metabolized excessively by Dipeptidyl Peptidase IV (DPP-IV) into inactive ...
Antidiabetic Effect of Urena lobata: Preliminary Study on Hexane, Ethanolic, and Aqueous Leaf Extracts

Wahyuningsih, Doti; Purnomo, Yudi (Jurnal Universitas Brawijaya, 2018-02-20)

Chronic hyperglycemia is one of the signs of human type-2 diabetes mellitus due to insulin resistance and depletion. This study aimed to evaluate hexane, ethanolic, and aqueous leaf extracts of Urena lobata as antihyperglycemic ...
EFEK EKSTRAK ETANOL DAUN GEDI MERAH (Abelmoschus manihot (L.) Medik) TERHADAP KADAR SOD DAN MDA PADA AORTA TIKUS MODEL DIABETES MELITUS TIPE 2

Purnomo, Yudi; Putra Sanjaya, Hendra; Annis Pramesti, Fathia (Jurnal Kesehatan Islam - Fakultas Kedokteran, Universitas Islam Malang, 2020-03-01)

Hiperglikemia pada diabetes melitus (DM) meningkatkan produksi reactive oxygen species (ROS) yang berperan terhadap komplikasi makroangiopati diabetik. Daun gedi merah dikenal memiliki efek antioksidan dan antihiperglikemia ...
EFEK EKSTRAK ETANOL DAUN GEDI MERAH (ABELMOSCHUS MANIHOT (L.) MEDIK) TERHADAP KADAR SUPEROXIDE DISMUTASE DAN MALONDIALDEHYDE JARINGAN GINJAL TIKUS MODEL DIABETES MELITUS TIPE 2

Purnomo, Yudi; Fuadi, Ahmad; Arif Martino, Yoyon (Jurnal Kesehatan Islam - Fakultas Kedokteran, Universitas Islam Malang, 2020-09-12)

Hiperglikemia pada Diabetes Melitus (DM) meningkatkan produksi Reactive Oxygen Species (ROS) dan berperan terhadap risiko komplikasi nefropati diabetik. Daun gedi merah (Abelmoschus manihot (L.) Medik) berkhasiat sebagai ...
EFEK EKSTRAK ETANOL DAUN GEDI MERAH (Abelmoschus manihot (L.) Medik) TERHADAP PERSENTASE INTERLEUKIN-10 (IL-10) DAN SEL T SITOTOKSIK (CD8+ ) TIKUS MODEL DIABETES Tipe II

Purnomo, Yudi; Kamilah, Nur; Hakim, Reza (Jurnal Kesehatan Islam - Fakultas Kedokteran, Universitas Islam Malang, 2019-03-01)

Inflamasi akibat kerusakan oksidatif yang dipicu hiperglikemia berperan terhadap progresivitas diabetes melitus (DM). Interleukin-10 (IL-10) dan CD8+ berpengaruh terhadap proses inflamasi. Abelmoschus manihot (L.) Medik ...
EFEK KOMBINASI SEFTRIAKSON DAN KLORAMFENIKOL PADA Staphylococcus aureus DARI ISOLAT GANGREN DIABETIK

Purnomo, Yudi; Chandra, Pasha; Triliana, Rahma (Jurnal Farmasi Galenika, 2022-03-01)

Diabetic gangrene is a complication of Diabetes mellitus caused by Staphylococcus aureus. The combination of Ceftriaxone and Chloramphenicol is often used to cure gangrene infection, even though, they produce antagonist ...
Effect of ascorbic acid, α-tocopherol and its combination on human umbilical vein endothelial cells permeability exposed to high concentration of glucose

Purnomo, Yudi; Soeatmadji, Djoko W; Widodo, M Aris (Russian Open Medical Journal, 2019-05-28)

Aim — To evaluate the effect of ascorbic acid, α-tocopherol, and its combination on the permeability of human umbilical vein endothelial cells (HUVEC’S) culture after high glucose concentration exposure. Material and ...
Effect of Pulutan (Urena lobata) Leaf Extract on Blood Glucose Level, Hemoglobin and Body Growth of Zebra Fish (Danio rerio) Exposed to Malathion

Purnomo, Yudi; Pamungkas, Iqbal A; Sofiani, Mita; Pratama, Sumanjaya (Tropical Journal of Natural Product Research (TJNPR), 2021-06-01)

Pulutan (Urena lobata) is a medicinal plant having antioxidant activity. However, their potency to inhibit the adverse effects of malathion has not been evaluated. The study aims to examine Urena lobata (U. lobata) leaves ...
In Silico Study of Pulutan (Urena lobata) Leaf Extract as Anti Inflammation and their ADME Prediction

Wahyuningsih, Doti; Purnomo, Yudi; Tilaqza, Andri (Journal of Tropical Pharmacy and Chemistry (JTPC), 2022-06-30)

Inflammation is the basic for the pathogenesis of several diseases both of degenerative and non-degenerative disease. Urena lobata is a medicinal plant that can be found in Indonesia and has been used traditionally to cure ...
Incretin effect of Urena lobata leaves extract on structure and function of rats islet β-cells

Purnomo, Yudi; Soeatmadji, D.W; Sumitro, S.B; Widodo, M.A (Elsevier, 2017-07-20)

This study aims to determine the incretin effects of Urena lobata leaves extract on the structure and function of rats islet β-cells. This study utilizes male Sprague-Dawley rats divided into 2 control group and 3 test ...
Inhibitory activity of Urena lobata leaf extract on alpha-amylase and alpha-glucosidase: in vitro and in silico approach

Purnomo, Yudi; Makdasari, Juliah; Inayah Fatahillah, Faiqoh (Journal of Basic and Clinical Physiology and Pharmacology, 2021-11-21)

In food ingestion, alpha-glucosidase (α-glucosidase) and alpha-amylase (α-amylase) are enzymes that are responsible to convert a carbohydrate into glucose. Inhibition of both enzyme activities can prolong absorption of ...
Inhibitory activity of Urena lobata leaf extract on dipeptidyl peptidase-4 (DPP-4): Is it different in vitro and in vivo?

Purnomo, Yudi; Soeatmadji, D.W; Sumitro, S.B; Widodo, Moch Aris (Medicinal Plants - International Journal of Phytomedicines and Related Industries, 2018-05-28)

This study was aimed to compare the anti diabetic effect of Urena lobata leaf extract through DPP-4 inhibitory activity by in vitro and in vivo. Urena lobata leaf was extracted in ethanol and hot water to evaluate its ...
Molecular Docking of Soybean (Glycine max) Seed and Ginger (Zingiber officinale) Rhizome Components as Anti-Diabetic Through Inhibition of Dipeptidyl Peptidase 4 (DPP-4) and Alpha-Glucosidase Enzymes

Purnomo, Yudi; Taufiq, Muhammad; Wijaya, Afnan N. D.; Hakim, Reza (Tropical Journal of Natural Product Research, 2021-10-01)

Dipeptidyl Peptidase-4 (DPP-4) and alpha-glucosidase (α-glucosidase) are enzymes involved in carbohydrate metabolism. Inhibition of these enzymes contribute to blood glucose level suppression. Soybean (Glycine max) seeds ...
Potensi Toleransi Oral Glukosa Ekstrak Biji Kedelai (Glycine Max), Rimpang Jahe (Zingiber Officinale) Dan Kombinasinya Pada Tikus Model Diabetes

Purnomo, Yudi (Jurnal Kesehatan Islam (JKI), 2018-09-20)

Diabetes Mellitus (DM) adalah sindrom metabolik yang ditandai peningkatan kadar glukosa darah kronik dan berkontribusi terhadap beberapa resiko komplikasi. Biji Kedelai(G.max) danrimpang Jahe (Z.officinale) digunakan sebagai ...

Browsing LP - Faculty of Medicine by Author "Purnomo, Yudi"

Browsing LP - Faculty of Medicine by Author "Purnomo, Yudi"

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